21-day Greek isles & Adriatic: Italy & Istanbul overnight

Your voyage begins in Barcelona, Spain. The 1992 Summer Olympics revealed to the world what Europeans and seasoned travelers already knew - Barcelona is one of the world's greatest treasures. Vibrant and earthy, commercial and cultural, this city of two million residents is the capital of Spain's autonomous region of Catalonia. Stroll along the wide, tree-lined promenades of Las Ramblas and marvel at the spires of Gaudi's Basilica La Sagrada Familia. Or visit the former Olympic Ring on the hill of Montjuic - also home to world-class parks, fountains and museums. Barcelona, which nurtured such artistic giants as Picasso, Dali, Miro and Casals, is definitely a traveler's paradise.

Your ship calls at Villefranche-sur-Mer (Nice), France.

Livorno is the gateway to glorious Tuscany. Visit Florence - the cradle of the Renaissance - home to the Duomo, the Uffizi and the Ponte Vecchio. Here the Medici fostered a city-state whose cultural legacy is as great as classical Athens. Giants like Dante, Da Vinci, Michelangelo and Galileo infused the West with a new creative spirit. Then there is Pisa, Florence's rival for political power. Pisa, a brash, commercial seafaring town rivaled the great maritime powers of Venice and Genoa. The city was a leader in art and architecture second only to Florence.

Your gateway to the Eternal City, Civitavecchia has served as Rome's seaport since the 13th century. The port has a long and venerable history. The emperor Trajan built a pleasure villa near the modern city, while Bernini and Michelangelo designed the harbor fortifications.Yet the Eternal City eternally beckons. The ancient capital of the Western World and the center of Christianity for nearly 2,000 years, Rome provides an inexhaustible feast. Visit the ruins of the Forum, view the splendors of the Sistine Chapel, or climb the Spanish Steps, once the heart of Rome's Bohemian Quarter.Rome has been a magnet luring the world's greatest artists, architects, and philosophers since the days of the Caesars.

Italy's third-largest city, Naples is a bustling metropolis famed for it stately buildings, crowded streets, pizza - and notoriously bad traffic. However, this beautiful city is rich in centuries-old culture and customs. Naples is also your gateway to the Isle of Capri, the fabled Amalfi Coast and the ruins of Pompeii, buried in ash by the cataclysmic eruption of Mt. Vesuvius in 79 A.D. Naples boasts an ideal location, with both the ruins of Roman cities and the stunning Amalfi Coast in easy reach.

Your ship calls at Taormina, Italy.

A full day at sea - time to enjoy Nieuw Amsterdam's restaurants, pools and entertainment.

Your ship calls at Souda (Chania), Greece.

The largest and arguably the most beautiful of the 12 islands forming the Dodecanese, Rhodes has long played a major role in history. Lying just 12 miles off the coast of Turkey, the island straddles the sea-lanes linking Egypt, Southern Europe and the Holy Land. Rhodes Town bears witness to that long history. The ancient city features a classical stadium and the ruins of the Temple of Apollo. The "old" city is a walled town with medieval buildings and streets harking back to the days of the Crusades. The new town is a Mecca of luxury resorts lining the island's picturesque Mandaraki Harbor.The Colossus of Rhodes, one of the Seven Wonders of the Ancient World, is reputed to have once stood guard over the harbor. Today, the bronze statues of a stag and doe top the two columns marking the harbor entrance.

From the port of Kusadasi on Turkey's Anatolian Coast, one travels into the past. Nearby stand the ruins of ancient Ephesus, a major site of archeological excavation. The city was once a Roman provincial capital and trading center. Ephesus is also home to several of Christendom's holiest sites. St. Paul preached at the Great Theater and the ruins of Ephesus' Basilica cover the tomb of Christ's most beloved disciple, St. John the Apostle.In Kusadasi, whitewashed stone houses rise in tiers behind the market district. The palm-lined esplanade is the center of town life, with thousands of merchants offering wares to rival the Grand Bazaar in Istanbul.

The past maintains a vibrant presence in the cradle of Western civilization. Atop the Acropolis, the serene Parthenon sails above the commotion of the modern city. The tragedies of Aeschylus, Sophocles, and Euripides were performed in the Theater of Dionysus at the foot of the Acropolis. On Pnyx Hill, citizens of a fledgling democracy gathered to cast their votes on Athens' destiny. Then there is the hustle and bustle of the modern city, a metropolis of 4.5 million that spreads out from the foot of Mt. Lycabettus and across the plain. Packed with busy shops and lively tavernas, modern Athens is a colorful counterpoint to classical Greece. Piraeus is the port city for Athens and has been Athens' port of entry for over two millennia.

Your ship returns to Kusadasi, Turkey (for Ephesus).

Your ship calls at Cruising The Dardanelles.

Istanbul rises from the Bosphorus, a vision of minarets and domes sparkling in the light. The capital of vanished empires, Istanbul is a true crossroad, the only city on Earth to span two continents. This meeting place of Europe and Asia, of Christian and Muslim, is one of the great adventures a traveler encounters. Browse the stalls of the world's largest bazaar, explore ancient mosques and churches, and gaze at the stunning jewels in the Topkapi Palace.Istanbul has dominated the Straits of Bosphorus for 25 centuries. As Constantinople, capital of the Eastern Roman Empire, it was a metropolis of stunning splendor when the great cities of Europe were mere villages.

A second day in Istanbul, Turkey - time to explore at your own pace.

Thanks to its proximity to the mainland, Mykonos was one of the first Greek islands to become an international travel destination. During the late '60s and early '70s, Mykonos was famed as a haunt for the rich. The island's nightlife - then and now - was a glittering whirl of colored lights, music, and parties. But there's another side to Mykonos - the neighboring island of Delos. In classical mythology, Delos was the birthplace of Apollo and his twin sister Artemis. Travelers to Delos can stroll among the island's vast ruins, which include three temples consecrated to the Sun God and the famed Lions Walk.Mykonos town features hip boutiques, restaurants, jewelry stores, souvenirs, taverns and cafés. The island's famed windmills are found just south of the waterfront.

Your ship returns to Souda (Chania), Greece.

Perched on the west coast of the Peloponnesus, Greece's largest peninsula, this sleepy fishing village of some 300 souls is your gateway to Olympia, site of the original Olympic Games. Held every four years between 776 B.C. and 393 A.D., when the Emperor Theodosius banned pagan festivals, the Olympic Games celebrated the ideal harmony of mind and body. Every four years, the sacred flame of Altis is rekindled to light the torch for the Modern Games.Olympia's temples were destroyed after the games were banned. An earthquake in the 6th century compounded the destruction, and floods buried the site. Excavation of the ruins began in 1875, and Olympia was declared a National Park in 1976.

Your ship calls at Sarande, Albania.

Dubrovnik is a beautiful stone jewel hugging the Adriatic Sea. This picture-perfect medieval walled city offers ancient stone buildings, narrow cobbled streets and fortified ramparts rising above red-tiled rooftops. Stradun is the city's focal point and main artery while Dubrovnik's streets are blessedly free of vehicular traffic. Despite the heavy damage inflicted by shelling in the early '90s, Dubrovnik has been restored to its pre-war beauty. A UNESCO World Heritage Site, the old city remains the pride of the Republic of Croatia.For six centuries Dubrovnik was an independent republic - an oligarchy ruled by patrician families. The Republic was overthrown by Napoleon in 1808.Note: All passengers must carry an original photo I.D. when going ashore: photocopies are not accepted.On occasion, Dubrovnik will be an anchorage port; passengers transfer to shore via ship's tender.

Continue your voyage aboard Nieuw Amsterdam with a leisurely day at sea.

Tucked in the country's northeast corner on the Adriatic Sea and once the flourishing port of the Austro-Hungarian Empire, Trieste became a largely forgotten borderland after World War I. But today, those who visit find a blend of cultures and languages of Europe, with a rich literary legacy - a city that's lured great authors from Ranier Maria Rilke to James Joyce. Waves from the Adriatic lap its elegant promenades. It lies below the Karst, limestone cliffs that are a popular destination for nature lovers and where vineyards produce wines that taste of sea and stone. Legend has it Jason and the Argonauts - with the golden fleece - sailed in from an underground river. A well-preserved Roman theater, that once seated up to 6,000 spectators, is testimony that in antiquity, this was a thriving city. Gilded mosaics in San Giusto Cathedral are evidence of Byzantine influence. Trieste offers endless opportunity for exploration not only in the town and surroundings, but also to neighboring Slovenia and not so far distant Venice.