21-day Mediterranean crossing: Greek isles, Italy & Spain

Your voyage begins in Istanbul, Turkey. Istanbul rises from the Bosphorus, a vision of minarets and domes sparkling in the light. The capital of vanished empires, Istanbul is a true crossroad, the only city on Earth to span two continents. This meeting place of Europe and Asia, of Christian and Muslim, is one of the great adventures a traveler encounters. Browse the stalls of the world's largest bazaar, explore ancient mosques and churches, and gaze at the stunning jewels in the Topkapi Palace.Istanbul has dominated the Straits of Bosphorus for 25 centuries. As Constantinople, capital of the Eastern Roman Empire, it was a metropolis of stunning splendor when the great cities of Europe were mere villages.

A full day at sea - time to enjoy Rotterdam's restaurants, pools and entertainment.

Thanks to its proximity to the mainland, Mykonos was one of the first Greek islands to become an international travel destination. During the late '60s and early '70s, Mykonos was famed as a haunt for the rich. The island's nightlife - then and now - was a glittering whirl of colored lights, music, and parties. But there's another side to Mykonos - the neighboring island of Delos. In classical mythology, Delos was the birthplace of Apollo and his twin sister Artemis. Travelers to Delos can stroll among the island's vast ruins, which include three temples consecrated to the Sun God and the famed Lions Walk.Mykonos town features hip boutiques, restaurants, jewelry stores, souvenirs, taverns and cafés. The island's famed windmills are found just south of the waterfront.

Your ship calls at Souda (Chania), Greece.

Continue your voyage aboard Rotterdam with a leisurely day at sea.

Your ship calls at Messina, Italy.

Your ship calls at Cruising Strait of Messina.

Your ship calls at Evening cruising Stromboli Volcano.

Italy's third-largest city, Naples is a bustling metropolis famed for it stately buildings, crowded streets, pizza - and notoriously bad traffic. However, this beautiful city is rich in centuries-old culture and customs. Naples is also your gateway to the Isle of Capri, the fabled Amalfi Coast and the ruins of Pompeii, buried in ash by the cataclysmic eruption of Mt. Vesuvius in 79 A.D. Naples boasts an ideal location, with both the ruins of Roman cities and the stunning Amalfi Coast in easy reach.

Your gateway to the Eternal City, Civitavecchia has served as Rome's seaport since the 13th century. The port has a long and venerable history. The emperor Trajan built a pleasure villa near the modern city, while Bernini and Michelangelo designed the harbor fortifications.Yet the Eternal City eternally beckons. The ancient capital of the Western World and the center of Christianity for nearly 2,000 years, Rome provides an inexhaustible feast. Visit the ruins of the Forum, view the splendors of the Sistine Chapel, or climb the Spanish Steps, once the heart of Rome's Bohemian Quarter.Rome has been a magnet luring the world's greatest artists, architects, and philosophers since the days of the Caesars.

Livorno is the gateway to glorious Tuscany. Visit Florence - the cradle of the Renaissance - home to the Duomo, the Uffizi and the Ponte Vecchio. Here the Medici fostered a city-state whose cultural legacy is as great as classical Athens. Giants like Dante, Da Vinci, Michelangelo and Galileo infused the West with a new creative spirit. Then there is Pisa, Florence's rival for political power. Pisa, a brash, commercial seafaring town rivaled the great maritime powers of Venice and Genoa. The city was a leader in art and architecture second only to Florence.

Another day at sea to explore the ship at your own pace.

Cartagena is an ancient port - the city served as Hannibal's Spanish headquarters during the 2nd Punic War with Rome. The city remained a major trading port under the Romans and the Moors. Today, Cartagena is Spain's principal naval establishment and the site of an annual international maritime festival. The city is also your gateway to the Costa Calida, a region that boasts some of Spain's mildest weather along with 175 miles of beaches.

The Rock crouches over the sea like an ancient stone beast, looking Sphinx-like to Africa. Beneath the white cliffs of this natural fortress grows a profusion of palm, pine, and cypress. No fewer than 600 varieties of flowers thrive here, some not found anywhere else on Earth. Gibraltar's stunning setting is matched by its history - five countries have battled for 13 centuries to control the passage between the Atlantic and the Mediterranean. The result made for a cultural melting pot. Veiled Moroccan women in caftans and vacationing Englishmen and Spaniards stroll along the narrow, steep lanes. The locals revert to a liquid Spanish when talking among themselves. And visitors to a 15th-century cathedral pass through a blue-tiled courtyard, once part of a 13th-century mosque.Helmeted bobbies, pillar-boxes and pubs make for a bit of Britain in the Mediterranean. Gibraltar is a fascinating place, from its caves and batteries to the Barbary apes gamboling on the slopes of the Rock.

A full day at sea - time to enjoy Rotterdam's restaurants, pools and entertainment.

Continue your voyage aboard Rotterdam with a leisurely day at sea.

Another day at sea to explore the ship at your own pace.

A full day at sea - time to enjoy Rotterdam's restaurants, pools and entertainment.

Continue your voyage aboard Rotterdam with a leisurely day at sea.

Another day at sea to explore the ship at your own pace.

A full day at sea - time to enjoy Rotterdam's restaurants, pools and entertainment.

Continue your voyage aboard Rotterdam with a leisurely day at sea.

Another day at sea to explore the ship at your own pace.

According to the popular 1960 beach movie, Fort Lauderdale is "where the boys are." The city's reputation as America's Spring Break capital, however, has been replaced with the more favorable image of a prime family tourist destination, attracting more than 10 million visitors annually. The most popular beach resort in Florida is even more rightly famed as the "Yachting Capital of the World," with more than 40,000 registered crafts calling its waters home. The city also prides itself on being the "Venice of America" with more than 300 miles of navigable waterways. Fort Lauderdale boasts world-class theaters, museums, sightseeing, and shopping. The city sits 24 miles north of Miami and is named after a series of forts built by the United States during the second Seminole War. The forts took their name from Major William Lauderdale, who was the commander of the detachment of soldiers who built the first fort. Look hard and you might find remnants of three of them today. More people seem to be interested in taking a water tour aboard the "Carrie B."